Human EVI-1 protein (Recombinant) (His-Tag) (STJP018526)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human EVI-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MECOM |
| Gene ID | 2122 |
| Uniprot ID | MECOM_HUMAN |
| Accession Number | NP_004982.1 |
| Immunogen | Human |
| Immunogen Region | 1-169aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated. May be acetylated by CREBBP and KAT2B. |
| Function | Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Isoform 7: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. |
| Protein Name | Histone-Lysine N-Methyltransferase MecomEcotropic Virus Integration Site 1 Protein HomologEvi-1Mds1 And Evi1 Complex Locus ProteinMyelodysplasia Syndrome 1 ProteinMyelodysplasia Syndrome-Associated Protein 1 |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-8943724Reactome: R-HSA-9830364 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Protein Names | Histone-Lysine N-Methyltransferase Mecom proteinEcotropic Virus Integration Site 1 Protein Homolog proteinEvi-1 proteinMds1 And Evi1 Complex Locus Protein proteinMyelodysplasia Syndrome 1 Protein proteinMyelodysplasia Syndrome-Associated Protein 1 proteinMECOM proteinEVI1 proteinMDS1 proteinPRDM3 protein |
Information sourced from Uniprot.org