Human ESRP1 protein (Recombinant) (N-His) (STJP008990)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ESRP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ESRP1 |
| Gene ID | 54845 |
| Uniprot ID | ESRP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser193 |
Additional Info
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. |
| Protein Name | Epithelial Splicing Regulatory Protein 1Rna-Binding Motif Protein 35aRna-Binding Protein 35a |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-6803529 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Epithelial Splicing Regulatory Protein 1 proteinRna-Binding Motif Protein 35a proteinRna-Binding Protein 35a proteinESRP1 proteinRBM35A protein |
Information sourced from Uniprot.org