Human ERLIN1 protein (Recombinant) (N-His) (STJP008333)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ERLIN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ERLIN1 |
| Gene ID | 10613 |
| Uniprot ID | ERLN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu29-Thr173 |
Additional Info
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1Endoplasmic Reticulum Lipid Raft-Associated Protein 1Protein Ke04Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Protein Names | Erlin-1 proteinEndoplasmic Reticulum Lipid Raft-Associated Protein 1 proteinProtein Ke04 proteinStomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 proteinSpfh Domain-Containing Protein 1 proteinERLIN1 proteinC10orf69 proteinKE04 proteinKEO4 proteinSPFH1 protein |
Information sourced from Uniprot.org