Human ERLIN1 (ER Lipid Raft Associated Protein 1) Sandwich ELISA Kit (STJE0008701)
SPECIFICATIONS
General Information
| Short Description | This ERLIN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.107ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | ERLIN1 |
| Gene ID | 10613 |
| Uniprot ID | ERLN1_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. |
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1Endoplasmic Reticulum Lipid Raft-Associated Protein 1Protein Ke04Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative ELISA Names | Erlin-1 ELISA kitEndoplasmic Reticulum Lipid Raft-Associated Protein 1 ELISA kitProtein Ke04 ELISA kitStomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 ELISA kitSpfh Domain-Containing Protein 1 ELISA kitERLIN1 ELISA kitC10orf69 ELISA kitKE04 ELISA kitKEO4 ELISA kitSPFH1 ELISA kit |
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Information sourced from Uniprot.org