Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696)
SPECIFICATIONS
General Information
| Short Description | This ERFE Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.055ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | ERFE |
| Gene ID | 151176 |
| Uniprot ID | ERFE_HUMAN |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | N-glycosylated.required for secretion of the mature protein. |
| Function | Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling. Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway. Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling. The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption. |
| Protein Name | ErythroferroneComplement C1q Tumor Necrosis Factor-Related Protein 15Myonectin |
| Database Links | |
| Cellular Localisation | SecretedSecreted When Glycosylated At Asn-243 And Asn-295Hydroxylation Promotes Secretion |
| Alternative ELISA Names | Erythroferrone ELISA kitComplement C1q Tumor Necrosis Factor-Related Protein 15 ELISA kitMyonectin ELISA kitERFE ELISA kitC1QTNF15 ELISA kitCTRP15 ELISA kitFAM132B ELISA kit |
| output |
Information sourced from Uniprot.org