| Host: | Mouse/Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This ErbB3 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: | Colormetric |
| Gene Symbol: | ERBB3 |
| Gene ID: | 2065 |
| Uniprot ID: | ERBB3_HUMAN |
| Immunogen: | Capture immunogen: Recombinant Human ErbB3 protien.Detection Immunogen: Recombinant Human ErbB3 protien. |
| Sample Type: | Serum, plasma and other biological fluids |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1Reactome: R-HSA-1236394 P21860-1Reactome: R-HSA-1250196 P21860-1Reactome: R-HSA-1257604 P21860-1Reactome: R-HSA-1306955 P21860-1Reactome: R-HSA-1358803 P21860-1Reactome: R-HSA-1963642 P21860-1Reactome: R-HSA-2219530 P21860-1Reactome: R-HSA-5673001 P21860-1Reactome: R-HSA-6785631 P21860-1Reactome: R-HSA-6811558 P21860-1Reactome: R-HSA-8847993 P21860-1Reactome: R-HSA-8863795 P21860-1Reactome: R-HSA-9664565 P21860-1Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Pair Names | Receptor Tyrosine-Protein Kinase Erbb-3 antibody pairProto-Oncogene-Like Protein C-Erbb-3 antibody pairTyrosine Kinase-Type Cell Surface Receptor Her3 antibody pairERBB3 antibody pairHER3 antibody pair |
Information sourced from Uniprot.org
