Human ERAP2 protein (Recombinant-Active) (N-10*His) (STJP012164)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human ERAP2-N-10*His protein was developed from mammalian cells and has a target region of N-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (Arg-AMC). The specific activity is >50 pmol/min/µg, as measured under the described conditions. |
Target Information
| Gene Symbol | ERAP2 |
| Gene ID | 64167 |
| Uniprot ID | ERAP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala56-Thr960 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 2Leukocyte-Derived Arginine AminopeptidaseL-Rap |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Endoplasmic Reticulum Aminopeptidase 2 proteinLeukocyte-Derived Arginine Aminopeptidase proteinL-Rap proteinERAP2 proteinLRAP protein |
Information sourced from Uniprot.org