Human ERAP1 protein (Recombinant) (N-His) (STJP008173)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ERAP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ERAP1 |
| Gene ID | 51752 |
| Uniprot ID | ERAP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly529-Met941 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 1Arts-1Adipocyte-Derived Leucine AminopeptidaseA-LapAminopeptidase PilsPuromycin-Insensitive Leucyl-Specific AminopeptidasePils-ApType 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Endoplasmic Reticulum Aminopeptidase 1 proteinArts-1 proteinAdipocyte-Derived Leucine Aminopeptidase proteinA-Lap proteinAminopeptidase Pils proteinPuromycin-Insensitive Leucyl-Specific Aminopeptidase proteinPils-Ap proteinType 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator proteinERAP1 proteinAPPILS proteinARTS1 proteinKIAA0525 proteinUNQ584 proteinPRO1154 protein |
Information sourced from Uniprot.org