Human Ephrin-B3 protein (Recombinant) (His-Tag) (STJP017767)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Ephrin-B3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 2M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EFNB3 |
| Gene ID | 1949 |
| Uniprot ID | EFNB3_HUMAN |
| Accession Number | NP_001397 |
| Immunogen | Human |
| Immunogen Region | 28-226aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in brain.expressed in embryonic floor plate, roof plate and hindbrain segments. |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for nipah virus and hendra virus. |
| Protein Name | Ephrin-B3Eph-Related Receptor Transmembrane Ligand Elk-L3Eph-Related Receptor Tyrosine Kinase Ligand 8Lerk-8 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Ephrin-B3 proteinEph-Related Receptor Transmembrane Ligand Elk-L3 proteinEph-Related Receptor Tyrosine Kinase Ligand 8 proteinLerk-8 proteinEFNB3 proteinEPLG8 proteinLERK8 protein |
Information sourced from Uniprot.org