Human Ephrin-B1 protein (Recombinant) (His-Tag) (STJP017320)

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STJP017320
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Ephrin-B1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 5% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: EFNB1
Gene ID: 1947
Uniprot ID: EFNB1_HUMAN
Immunogen Region: 28-237aa
Accession Number: NP_004420
Immunogen: Human
Immunogen Sequence: LAKNLEPVS WSSLNPKFLS GKGLVIYPKI GDKLDIICPR AEAGRPYEYY KLYLVRPEQA AACSTVLDPN VLVTCNRPEQ EIRFTIKFQE FSPNYMGLEF KKHHDYYITS TSNGSLEGLE NREGGVCRTR TMKIIMKVGQ DPNAVTPEQL TTSRPSKEAD NTVKMATQAP GSRGSLGDSD GKHETVNQEE KSGPGASGGS SGDPDG
Tissue Specificity Widely expressed. Detected in both neuronal and non-neuronal tissues. Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name Ephrin-B1
Efl-3
Elk Ligand
Elk-L
Eph-Related Receptor Tyrosine Kinase Ligand 2
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain
Ephrin-B1 Icd
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
May Recruit Grip1 And Grip2 To Membrane Raft Domains
Ephrin-B1 C-Terminal Fragment: Cell Membrane
Ephrin-B1 Intracellular Domain: Nucleus
Colocalizes With Zhx2 In The Nucleus
Alternative Protein Names Ephrin-B1 protein
Efl-3 protein
Elk Ligand protein
Elk-L protein
Eph-Related Receptor Tyrosine Kinase Ligand 2 protein
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment protein
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain protein
Ephrin-B1 Icd protein
EFNB1 protein
EFL3 protein
EPLG2 protein
LERK2 protein

Information sourced from Uniprot.org

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