SDS-PAGE gel of recombinant human Ephrin-B2 protein 3µg under reducing conditions with Coomassie blue staining

Human Ephrin-B2 protein (Recombinant) (His-Tag) (STJP017347)

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STJP017347
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Short Description :Recombinant-Human Ephrin-B2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 40% Glycerol, 200mM NaCl, 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:EFNB2
Gene ID:1948
Uniprot ID:EFNB2_HUMAN
Accession Number:NP_004084.1
Immunogen:Human
Immunogen Region:28-229aa
Immunogen Sequence:IVLEP IYWNSSNSKF LPGQGLVLYP QIGDKLDIIC PKVDSKTVGQ YEYYKVYMVD KDQADRCTIK KENTPLLNCA KPDQDIKFTI KFQEFSPNLW GLEFQKNKDY YIISTSNGSL EGLDNQEGGV CQTRAMKILM KVGQDASSAG STRNKDPTRR PELEAGTNGR SSTTSPFVKP NPGSSTDGNS AGHSGNNILG SEVALF
Tissue Specificity Lung and kidney.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Protein Name Ephrin-B2
Eph-Related Receptor Tyrosine Kinase Ligand 5
Lerk-5
Htk Ligand
Htk-L
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Alternative Protein Names Ephrin-B2 protein
Eph-Related Receptor Tyrosine Kinase Ligand 5 protein
Lerk-5 protein
Htk Ligand protein
Htk-L protein
EFNB2 protein
EPLG5 protein
HTKL protein
LERK5 protein

Information sourced from Uniprot.org

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