human Ephrin-A3/EFNA3 protein (Recombinant) (C-6His) (STJP001894)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant human Ephrin-A3/EFNA3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ser 213) of human Ephrin-A3/EFNA3 (Accession #NP_004943.1.) fused with and a 6ΓHis tag at the C-terminus.
General Information
| Short Description | Recombinant-human Ephrin-A3/EFNA3-C-6His protein was developed in hek293 cells using the region Met 1-Ser 213. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human EFNA3 at 2 Mu g/mL (100 Mu L/well) can bind Human EphA3 with a linear range of 0.02-2.82 ng/mL. |
| Determination Method | < 0.01 EU/Mu g |
Target Information
| Gene Symbol | EFNA3 |
| Gene ID | 1944 |
| Uniprot ID | EFNA3_HUMAN |
| Immunogen | Recombinant human Ephrin-A3/EFNA3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ser 213) of human Ephrin-A3/EFNA3 (Accession #NP_004943.1.) fused with and a 6ΓHis tag at the C-terminus. |
| Immunogen Region | Met 1-Ser 213 |
| Immunogen Sequence | MAAAPLLLLLLLVPVPLLPL LAQGPGGALGNRHAVYWNSS NQHLRREGYTVQVNVNDYLD IYCPHYNSSGVGPGAGPGPG GGAEQYVLYMVSRNGYRTCN ASQGFKRWECNRPHAPHSPI KFSEKFQRYSAFSLGYEFHA GHEYYYISTPTHNLHWKCLR MKVFVCCASTSHSGEKPVPT LPQFTMGPNVKINVLEDFEG ENPQVPKLEKSIS |
Additional Info
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. |
| Protein Name | Ephrin-A3Efl-2Ehk1 LigandEhk1-LEph-Related Receptor Tyrosine Kinase Ligand 3Lerk-3 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Ephrin-A3 proteinEfl-2 proteinEhk1 Ligand proteinEhk1-L proteinEph-Related Receptor Tyrosine Kinase Ligand 3 proteinLerk-3 proteinEFNA3 proteinEFL2 proteinEPLG3 proteinLERK3 protein |
Information sourced from Uniprot.org