Human EPCR protein (Recombinant) (STJP000706)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encodingHuman Endothelial protein C receptor-EPCR (SER18-THR209 ) extracellular domain including a C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human EPCR-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
Target Information
| Gene Symbol | PROCR |
| Gene ID | 10544 |
| Uniprot ID | EPCR_HUMAN |
| Immunogen | Optimized DNA sequence encodingHuman Endothelial protein C receptor-EPCR (SER18-THR209 ) extracellular domain including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | SER18-THR209 |
Additional Info
| Tissue Specificity | Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. |
| Post Translational Modifications | N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. |
| Function | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation. |
| Protein Name | Endothelial Protein C ReceptorActivated Protein C ReceptorApc ReceptorEndothelial Cell Protein C ReceptorCd Antigen Cd201 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Endothelial Protein C Receptor proteinActivated Protein C Receptor proteinApc Receptor proteinEndothelial Cell Protein C Receptor proteinCd Antigen Cd201 proteinPROCR proteinEPCR protein |
Information sourced from Uniprot.org