Human EPCR protein (Recombinant) (Fc-Tag) (STJP000707)

Name: Human EPCR protein (Recombinant) (Fc-Tag) (STJP000707)
SKU: STJP000707
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostHEK293

ConjugationUnconjugated

ImmunogenDNA sequence encoding the extracellular domain of Human PROCR including a C-terminal human IgG1-Fc tag was expressed in HEK293 Cells. NA

STJP000707

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Short Description	Recombinant-Human EPCR-Fc-Tag protein was developed from hek293 and has a target region of Fc-Tag. For use in research applications.
Host	HEK293
Note	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Formulation	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA
Endotoxin	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol	PROCR
Gene ID	10544
Uniprot ID	EPCR_HUMAN
Immunogen	DNA sequence encoding the extracellular domain of Human PROCR including a C-terminal human IgG1-Fc tag was expressed in HEK293 Cells. NA
Immunogen Region	ECD
Immunogen Sequence	SQDASDGLQR LHMLQISYFR DPYHVWYQGN ASLGGHLTHV LEGPDTNTTI IQLQPLQEPE SWARTQSGLQ SYLLQFHGLV RLVHQERTLA FPLTIRCFLG CELPPEGSRA HVFFEVAVNG SSFVSFRPER ALWQADTQVT SGVVTFTLQQ LNAYNRTRYE LREFLEDTCV QYVQKHISAE NTKGSQTSRS NA

Tissue Specificity	Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Post Translational Modifications	N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Function	Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation.
Protein Name	Endothelial Protein C Receptor Activated Protein C Receptor Apc Receptor Endothelial Cell Protein C Receptor Cd Antigen Cd201
Database Links	Reactome: R-HSA-140875 Reactome: R-HSA-202733
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Endothelial Protein C Receptor protein Activated Protein C Receptor protein Apc Receptor protein Endothelial Cell Protein C Receptor protein Cd Antigen Cd201 protein PROCR protein EPCR protein

Information sourced from Uniprot.org