Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020223)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human Ep-CAM/TROP-1/CD326 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln24-Lys245) of Human Ep-CAM/TROP-1/CD326 fused with a His and Avi tag at the C-terminal.
General Information
| Short Description | Recombinant-Human Ep-CAM/TROP-1/CD326-C-His&Avi protein was developed in hek293 cells using the region Gln24-Lys245. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | EPCAM |
| Gene ID | 4072 |
| Uniprot ID | EPCAM_HUMAN |
| Immunogen | Biotinylated Recombinant Human Ep-CAM/TROP-1/CD326 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln24-Lys245) of Human Ep-CAM/TROP-1/CD326 fused with a His and Avi tag at the C-terminal. |
| Immunogen Region | Gln24-Lys245 |
Additional Info
| Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
| Post Translational Modifications | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Protein Name | Epithelial Cell Adhesion MoleculeEp-CamAdenocarcinoma-Associated AntigenCell Surface Glycoprotein Trop-1Epithelial Cell Surface AntigenEpithelial GlycoproteinEgpEpithelial Glycoprotein 314Egp314Hegp314Ks 1/4 AntigenKsaMajor Gastrointestinal Tumor-Associated Protein Ga733-2Tumor-Associated Calcium Signal Transducer 1Cd Antigen Cd326 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Lateral Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionColocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction |
| Alternative Protein Names | Epithelial Cell Adhesion Molecule proteinEp-Cam proteinAdenocarcinoma-Associated Antigen proteinCell Surface Glycoprotein Trop-1 proteinEpithelial Cell Surface Antigen proteinEpithelial GlycoproteinEgp proteinEpithelial Glycoprotein 314 proteinEgp314 proteinHegp314 proteinKs 1/4 Antigen proteinKsa proteinMajor Gastrointestinal Tumor-Associated Protein Ga733-2 proteinTumor-Associated Calcium Signal Transducer 1 proteinCd Antigen Cd326 proteinEPCAM proteinGA733-2 proteinM1S2 proteinM4S1 proteinMIC18 proteinTACSTD1 proteinTROP1 protein |
Information sourced from Uniprot.org