Human ENTPD5 protein (Recombinant) (N-His) (STJP010729)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ENTPD5-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ENTPD5 |
| Gene ID | 957 |
| Uniprot ID | ENTP5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn25-His428 |
Additional Info
| Post Translational Modifications | N-glycosylated.high-mannose type. Glycosylation is not essential for enzymatic activity. |
| Function | Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER. |
| Protein Name | Nucleoside Diphosphate Phosphatase Entpd5Cd39 Antigen-Like 4Er-UdpaseEctonucleoside Triphosphate Diphosphohydrolase 5Ntpdase 5Guanosine-Diphosphatase Entpd5Gdpase Entpd5Inosine Diphosphate Phosphatase Entpd5Nucleoside DiphosphataseUridine-Diphosphatase Entpd5Udpase Entpd5 |
| Database Links | Reactome: R-HSA-8850843Reactome: R-HSA-9660826 |
| Cellular Localisation | Endoplasmic ReticulumSecreted |
| Alternative Protein Names | Nucleoside Diphosphate Phosphatase Entpd5 proteinCd39 Antigen-Like 4 proteinEr-Udpase proteinEctonucleoside Triphosphate Diphosphohydrolase 5 proteinNtpdase 5 proteinGuanosine-Diphosphatase Entpd5 proteinGdpase Entpd5 proteinInosine Diphosphate Phosphatase Entpd5 proteinNucleoside Diphosphatase proteinUridine-Diphosphatase Entpd5 proteinUdpase Entpd5 proteinENTPD5 proteinCD39L4 proteinPCPH protein |
Information sourced from Uniprot.org