• Human ENPP-3 protein (Recombinant) (N-His-Avi) {Biotin} (STJP001611)

Human ENPP-3 protein (Recombinant) (N-His-Avi) {Biotin} (STJP001611)

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STJP001611

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human ENPP-3-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: ENPP3
Gene ID: 5169
Uniprot ID: ENPP3_HUMAN
Immunogen Region: Leu48-Ile875
Immunogen: DNA sequence encoding Human ENPP-3 including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.
Function Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3
E-Npp 3
Npp3
Phosphodiesterase I Beta
Pd-Ibeta
Phosphodiesterase I/Nucleotide Pyrophosphatase 3
Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase
Nppase
Nucleotide Diphosphatase
Database Links Reactome: R-HSA-199220
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Apical Cell Membrane
Secreted
Detected At The Cell Surface Of Basophils
Detected At The Apical Plasma Membrane Of Bile Duct Cells
Located To The Apical Surface In Intestinal And Kidney Epithelial Cells
Secreted In Serum
And In Lumen Of Epithelial Cells
Alternative Protein Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 protein
E-Npp 3 protein
Npp3 protein
Phosphodiesterase I Beta protein
Pd-Ibeta protein
Phosphodiesterase I/Nucleotide Pyrophosphatase 3 protein
Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase protein
Nppase protein
Nucleotide Diphosphatase protein
ENPP3 protein
PDNP3 protein

Information sourced from Uniprot.org

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