| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Post Translational Modifications | ISGylated. Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity. |
| Function | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Isoform MBP-1: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. |
| Protein Name | Alpha-Enolase2-Phospho-D-Glycerate Hydro-LyaseC-Myc Promoter-Binding ProteinEnolase 1Mbp-1Mpb-1Non-Neural EnolaseNnePhosphopyruvate HydratasePlasminogen-Binding Protein |
| Database Links | Reactome: R-HSA-70171Reactome: R-HSA-70263Reactome: R-HSA-9636667 |
| Cellular Localisation | CytoplasmCell MembraneMyofibrilSarcomereM LineCan Translocate To The Plasma Membrane In Either The Homodimeric (Alpha/Alpha) Or Heterodimeric (Alpha/Gamma) FormEno1 Is Localized To The M LineIsoform Mbp-1: Nucleus |
| Alternative Protein Names | Alpha-Enolase protein2-Phospho-D-Glycerate Hydro-Lyase proteinC-Myc Promoter-Binding Protein proteinEnolase 1 proteinMbp-1 proteinMpb-1 proteinNon-Neural Enolase proteinNne proteinPhosphopyruvate Hydratase proteinPlasminogen-Binding Protein proteinENO1 proteinENO1L1 proteinMBPB1 proteinMPB1 protein |
Information sourced from Uniprot.org
