Human EMD protein (Recombinant) (N-His) (STJP004849)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EMD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | EMD |
| Gene ID | 2010 |
| Uniprot ID | EMD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser66-Asn252 |
Additional Info
| Post Translational Modifications | Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle. |
| Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
| Protein Name | Emerin |
| Database Links | Reactome: R-HSA-2980766Reactome: R-HSA-2995383Reactome: R-HSA-4419969Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9609523 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Membrane ProteinNucleoplasmic SideNucleus Outer MembraneColocalized With Banf1 At The Central Region Of The Assembling Nuclear RimNear Spindle-Attachment SitesThe Accumulation Of Different Intermediates Of Prelamin-A/C (Non-Farnesylated Or Carboxymethylated Farnesylated Prelamin-A/C) In Fibroblasts Modify Its Localization In The Nucleus |
| Alternative Protein Names | Emerin proteinEMD proteinEDMD proteinSTA protein |
Information sourced from Uniprot.org