| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ELMO1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ELMO1 |
| Gene ID: | 9844 |
| Uniprot ID: | ELMO1_HUMAN |
| Immunogen Region: | Arg471-Asn727 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated by HCK. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 1Protein Ced-12 Homolog |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Plasma Membrane Seems To Be Mediated By Dock1 And Crk |
| Alternative Protein Names | Engulfment And Cell Motility Protein 1 proteinProtein Ced-12 Homolog proteinELMO1 proteinKIAA0281 protein |
Information sourced from Uniprot.org
