Human ELF3 protein (Recombinant) (N-His) (STJP015862)

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STJP015862
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Short Description :Recombinant-Human ELF3-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:ELF3
Gene ID:1999
Uniprot ID:ELF3_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Thr273-Asn371
Function Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGAAT. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Protein Name Ets-Related Transcription Factor Elf-3
E74-Like Factor 3
Epithelial-Restricted With Serine Box
Epithelium-Restricted Ets Protein Esx
Epithelium-Specific Ets Transcription Factor 1
Ese-1
Database Links Reactome: R-HSA-1912408
Cellular Localisation Cytoplasm
Nucleus
Localizes To The Cytoplasm Where It Has Been Shown To Transform Mcf-12a Mammary Epithelial Cells Via A Novel Cytoplasmic Mechanism
Also Transiently Expressed And Localized To The Nucleus Where It Induces Apoptosis In Non-Transformed Breast Epithelial Cells Mcf-10a And Mcf-12a Via A Transcription-Dependent Mechanism
Alternative Protein Names Ets-Related Transcription Factor Elf-3 protein
E74-Like Factor 3 protein
Epithelial-Restricted With Serine Box protein
Epithelium-Restricted Ets Protein Esx protein
Epithelium-Specific Ets Transcription Factor 1 protein
Ese-1 protein
ELF3 protein
ERT protein
ESX protein
JEN protein

Information sourced from Uniprot.org

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