Human ELANE protein (Recombinant) (N-GST) (STJP003833)

Name: Human ELANE protein (Recombinant) (N-GST) (STJP003833)
SKU: STJP003833
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP003833

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Short Description	Recombinant-Human ELANE-N-GST protein was developed from e.coli for the region N-GST. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.
Protein Name	Neutrophil Elastase Bone Marrow Serine Protease Elastase-2 Human Leukocyte Elastase Hle Medullasin Pmn Elastase
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-5620971 Reactome: R-HSA-6798695 Reactome: R-HSA-6803157 Reactome: R-HSA-977606 Reactome: R-HSA-9911233
Cellular Localisation	Cytoplasmic Vesicle Phagosome Localized In Phagolysosomes Following Ingestion Of E Coli By Neutrophils
Alternative Protein Names	Neutrophil Elastase protein Bone Marrow Serine Protease protein Elastase-2 protein Human Leukocyte Elastase protein Hle protein Medullasin protein Pmn Elastase protein ELANE protein ELA2 protein

Information sourced from Uniprot.org