| Function | ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes).specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S).the function is different from the established EJC assembly. Involved in craniofacial development. |
| Protein Name | Eukaryotic Initiation Factor 4a-IiiEif-4a-IiiEif4a-IiiAtp-Dependent Rna Helicase Ddx48Atp-Dependent Rna Helicase Eif4a-3Dead Box Protein 48Eukaryotic Initiation Factor 4a-Like Nuk-34Eukaryotic Translation Initiation Factor 4a Isoform 3Nuclear Matrix Protein 265Nmp 265Hnmp 265 Cleaved Into - Eukaryotic Initiation Factor 4a-Iii - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159236Reactome: R-HSA-429947Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9010553Reactome: R-HSA-975957Reactome: R-HSA-9820841Reactome: R-HSA-9820865 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmNucleocytoplasmic Shuttling ProteinTravels To The Cytoplasm As Part Of The Exon Junction Complex (Ejc) Bound To MrnaDetected In Dendritic Layer As Well As The Nuclear And Cytoplasmic (Somatic) Compartments Of NeuronsColocalizes With Stau1 And Fmr1 In Dendrites |
| Alternative Protein Names | Eukaryotic Initiation Factor 4a-Iii proteinEif-4a-Iii proteinEif4a-Iii proteinAtp-Dependent Rna Helicase Ddx48 proteinAtp-Dependent Rna Helicase Eif4a-3 proteinDead Box Protein 48 proteinEukaryotic Initiation Factor 4a-Like Nuk-34 proteinEukaryotic Translation Initiation Factor 4a Isoform 3 proteinNuclear Matrix Protein 265 proteinNmp 265 proteinHnmp 265 Cleaved Into - Eukaryotic Initiation Factor 4a-Iii - N-Terminally Processed proteinEIF4A3 proteinDDX48 proteinKIAA0111 protein |
Information sourced from Uniprot.org
