Human eIF-2B alpha/EIF2B1 protein (Recombinant) (His-Tag) (STJP017160)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human eIF-2B alpha/EIF2B1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF2B1 |
| Gene ID | 1967 |
| Uniprot ID | EI2BA_HUMAN |
| Accession Number | NP_001405.1 |
| Immunogen | Human |
| Immunogen Region | 1-305aa |
| Immunogen Sequence |
Additional Info
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. |
| Protein Name | Translation Initiation Factor Eif2b Subunit AlphaEif2b Gdp-Gtp Exchange Factor Subunit Alpha |
| Database Links | Reactome: R-HSA-72731 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Translation Initiation Factor Eif2b Subunit Alpha proteinEif2b Gdp-Gtp Exchange Factor Subunit Alpha proteinEIF2B1 proteinEIF2BA protein |
Information sourced from Uniprot.org