Human EHMT2 protein (Recombinant) (N-His) (STJP007897)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EHMT2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | EHMT2 |
| Gene ID | 10919 |
| Uniprot ID | EHMT2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly626-Thr918 |
Additional Info
| Post Translational Modifications | Methylated at Lys-185.automethylated. |
| Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. |
| Protein Name | Histone-Lysine N-Methyltransferase Ehmt2Euchromatic Histone-Lysine N-Methyltransferase 2Hla-B-Associated Transcript 8Histone H3-K9 Methyltransferase 3H3-K9-Hmtase 3Lysine N-Methyltransferase 1cProtein G9a |
| Database Links | Reactome: R-HSA-2559582Reactome: R-HSA-3214841Reactome: R-HSA-427389Reactome: R-HSA-6804760Reactome: R-HSA-73762Reactome: R-HSA-8853884Reactome: R-HSA-8953750Reactome: R-HSA-9843970 |
| Cellular Localisation | NucleusChromosomeAssociates With Euchromatic RegionsDoes Not Associate With Heterochromatin |
| Alternative Protein Names | Histone-Lysine N-Methyltransferase Ehmt2 proteinEuchromatic Histone-Lysine N-Methyltransferase 2 proteinHla-B-Associated Transcript 8 proteinHistone H3-K9 Methyltransferase 3 proteinH3-K9-Hmtase 3 proteinLysine N-Methyltransferase 1c proteinProtein G9a proteinEHMT2 proteinBAT8 proteinC6orf30 proteinG9A proteinKMT1C proteinNG36 protein |
Information sourced from Uniprot.org