Human EFEMP2 protein (Recombinant) (N-GST) (STJP003453)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EFEMP2-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | EFEMP2 |
| Gene ID | 30008 |
| Uniprot ID | FBLN4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser26-Phe443 |
Additional Info
| Function | Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. |
| Protein Name | Egf-Containing Fibulin-Like Extracellular Matrix Protein 2Fibulin-4Fibl-4Protein Uph1 |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneLocalizes On The Microfibrils Surrounding Eln Cores |
| Alternative Protein Names | Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 proteinFibulin-4 proteinFibl-4 proteinProtein Uph1 proteinEFEMP2 proteinFBLN4 proteinUNQ200 proteinPRO226 protein |
Information sourced from Uniprot.org