Human ECD protein (Recombinant) (N-His) (STJP010803)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ECD-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ECD |
| Gene ID | 11319 |
| Uniprot ID | ECD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met10-Asn406 |
Additional Info
| Post Translational Modifications | Phosphorylated predominantly by CK2 on two serine-containing clusters.involved in cell cycle regulation activity. |
| Function | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. Participates together with DDX39A in mRNA nuclear export. |
| Protein Name | Protein Ecdysoneless HomologHuman Suppressor Of Gcr TwoHsgt1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPredominantly Is Located In The Cytoplasm |
| Alternative Protein Names | Protein Ecdysoneless Homolog proteinHuman Suppressor Of Gcr Two proteinHsgt1 proteinECD protein |
Information sourced from Uniprot.org