Human DUSP26 protein (Recombinant) (His-Tag) (STJP018427)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DUSP26-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP26 |
| Gene ID | 78986 |
| Uniprot ID | DUS26_HUMAN |
| Accession Number | NP_076930 |
| Immunogen | Human |
| Immunogen Region | 1-211aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRL |
Additional Info
| Tissue Specificity | Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. |
| Function | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Protein Name | Dual Specificity Protein Phosphatase 26Dual Specificity Phosphatase Skrp3Low-Molecular-Mass Dual-Specificity Phosphatase 4Dsp-4Ldp-4Mitogen-Activated Protein Kinase Phosphatase 8Map Kinase Phosphatase 8Mkp-8Novel Amplified Gene In Thyroid Anaplastic Cancer |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusGolgi Apparatus |
| Alternative Protein Names | Dual Specificity Protein Phosphatase 26 proteinDual Specificity Phosphatase Skrp3 proteinLow-Molecular-Mass Dual-Specificity Phosphatase 4 proteinDsp-4 proteinLdp-4 proteinMitogen-Activated Protein Kinase Phosphatase 8 proteinMap Kinase Phosphatase 8 proteinMkp-8 proteinNovel Amplified Gene In Thyroid Anaplastic Cancer proteinDUSP26 proteinDUSP24 proteinLDP4 proteinMKP8 proteinNATA1 proteinSKRP3 protein |
Information sourced from Uniprot.org