Human DTNB protein (Recombinant) (N-His) (STJP003330)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DTNB-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DTNB |
| Gene ID | 1838 |
| Uniprot ID | DTNB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu249 |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A. |
| Function | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses. |
| Protein Name | Dystrobrevin BetaDtn-BBeta-Dystrobrevin |
| Database Links | Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmPostsynaptic DensityCell ProjectionDendriteBasal Cell MembranePostsynapseNucleusLocalized At Inhibitory Synapses On The Dendrites Of Cerebellar Purkinje Cells |
| Alternative Protein Names | Dystrobrevin Beta proteinDtn-B proteinBeta-Dystrobrevin proteinDTNB protein |
Information sourced from Uniprot.org