Human DSC1 protein (Recombinant) (N-His) (STJP005235)

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STJP005235
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DSC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DSC1
Gene ID: 1823
Uniprot ID: DSC1_HUMAN
Immunogen Region: Ala486-Asn686
Immunogen: Homo sapiens (Human)
Function A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation. Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood.
Protein Name Desmocollin-1
Cadherin Family Member 1
Desmosomal Glycoprotein 2/3
Dg2/Dg3
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Desmosome
Alternative Protein Names Desmocollin-1 protein
Cadherin Family Member 1 protein
Desmosomal Glycoprotein 2/3 protein
Dg2/Dg3 protein
DSC1 protein
CDHF1 protein

Information sourced from Uniprot.org

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