Human DROSHA protein (Recombinant) (N-GST) (STJP006081)

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STJP006081
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DROSHA-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DROSHA
Gene ID: 29102
Uniprot ID: RNC_HUMAN
Immunogen Region: His353-Ser550
Immunogen: Homo sapiens (Human)
Post Translational Modifications Degraded by autophagy in response to neuronal activity in motor neurons.
Function Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons.
Protein Name Ribonuclease 3
Protein Drosha
Ribonuclease Iii
Rnase Iii
P241
Database Links Reactome: R-HSA-203927
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
A Fraction Is Translocated To The Nucleolus During The S Phase Of The Cell Cycle
Localized In Gw Bodies (Gwbs)
Also Known As P-Bodies
Alternative Protein Names Ribonuclease 3 protein
Protein Drosha protein
Ribonuclease Iii protein
Rnase Iii protein
P241 protein
DROSHA protein
RN3 protein
RNASE3L protein
RNASEN protein

Information sourced from Uniprot.org

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