Human DROSHA protein (Recombinant) (N-GST) (STJP006081)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DROSHA-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DROSHA |
| Gene ID | 29102 |
| Uniprot ID | RNC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His353-Ser550 |
Additional Info
| Post Translational Modifications | Degraded by autophagy in response to neuronal activity in motor neurons. |
| Function | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons. |
| Protein Name | Ribonuclease 3Protein DroshaRibonuclease IiiRnase IiiP241 |
| Database Links | Reactome: R-HSA-203927 |
| Cellular Localisation | NucleusNucleolusCytoplasmA Fraction Is Translocated To The Nucleolus During The S Phase Of The Cell CycleLocalized In Gw Bodies (Gwbs)Also Known As P-Bodies |
| Alternative Protein Names | Ribonuclease 3 proteinProtein Drosha proteinRibonuclease Iii proteinRnase Iii proteinP241 proteinDROSHA proteinRN3 proteinRNASE3L proteinRNASEN protein |
Information sourced from Uniprot.org