Human INVS protein (Recombinant) (N-GST) (STJP006239)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human INVS-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | INVS |
| Gene ID | 27130 |
| Uniprot ID | INVS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys91 |
Additional Info
| Post Translational Modifications | May be ubiquitinated via its interaction with APC2. Hydroxylated at Asn-75, most probably by HIF1AN. |
| Function | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. |
| Protein Name | InversinInversion Of Embryo Turning HomologNephrocystin-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleMembranePeripheral Membrane ProteinNucleusCell ProjectionCiliumAssociates With Several Components Of The Cytoskeleton Including CiliaryRandom And Polarized MicrotubulesDuring MitosisIt Is Recruited To Mitotic SpindleFrequently Membrane-AssociatedMembrane Localization Is Dependent Upon Cell-Cell Contacts And Is Redistributed When Cell Adhesion Is Disrupted After Incubation Of The Cell Monolayer With Low-Calcium/Egta Medium |
| Alternative Protein Names | Inversin proteinInversion Of Embryo Turning Homolog proteinNephrocystin-2 proteinINVS proteinINV proteinNPHP2 protein |
Information sourced from Uniprot.org