Human DR1 protein (Recombinant) (His-Tag) (STJP016809)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DR1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 0.1mM PMSF, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DR1 |
| Gene ID | 1810 |
| Uniprot ID | NC2B_HUMAN |
| Accession Number | NP_001929.1 |
| Immunogen | Human |
| Immunogen Region | 1-176aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1. |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Protein Name | Protein Dr1Down-Regulator Of Transcription 1Negative Cofactor 2-BetaNc2-BetaTata-Binding Protein-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Protein Dr1 proteinDown-Regulator Of Transcription 1 proteinNegative Cofactor 2-Beta proteinNc2-Beta proteinTata-Binding Protein-Associated PhosphoproteinDR1 protein |
Information sourced from Uniprot.org