Human DPY30 protein (Recombinant) (His-Tag) (STJP018893)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DPY30-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DPY30 |
| Gene ID | 84661 |
| Uniprot ID | DPY30_HUMAN |
| Accession Number | NP_115963 |
| Immunogen | Human |
| Immunogen Region | 1-99aa |
| Immunogen Sequence |
Additional Info
| Function | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. |
| Protein Name | Protein Dpy-30 HomologDpy-30-Like ProteinDpy-30l |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | NucleusGolgi ApparatusTrans-Golgi NetworkAssociated With Chromatin At Regions Enriched In Histone H3 Trimethylated At 'Lys-4Highly Enriched In Gene Promoter Regions And 5' UtrsBut Not In Downstream Regions Of Genes Or 3' Utrs |
| Alternative Protein Names | Protein Dpy-30 Homolog proteinDpy-30-Like Protein proteinDpy-30l proteinDPY30 protein |
Information sourced from Uniprot.org