Human DPP8 protein (Recombinant) (N-His) (STJP006354)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DPP8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DPP8 |
| Gene ID | 54878 |
| Uniprot ID | DPP8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met8-Gln199 |
Additional Info
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 8Dp8Dipeptidyl Peptidase Iv-Related Protein 1Dprp-1Dipeptidyl Peptidase ViiiDpp ViiiProlyl Dipeptidase Dpp8 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Dipeptidyl Peptidase 8 proteinDp8 proteinDipeptidyl Peptidase Iv-Related Protein 1 proteinDprp-1 proteinDipeptidyl Peptidase Viii proteinDpp Viii proteinProlyl Dipeptidase Dpp8 proteinDPP8 proteinDPRP1 proteinMSTP097 proteinMSTP135 proteinMSTP141 protein |
Information sourced from Uniprot.org