Human Dopamine beta-Hydroxylase protein (Recombinant) (His-Tag) (STJP019117)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Dopamine beta-Hydroxylase-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DBH |
| Gene ID | 1621 |
| Uniprot ID | DOPO_HUMAN |
| Accession Number | NP_000778 |
| Immunogen | Human |
| Immunogen Region | 40-617aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. |
| Function | Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. |
| Protein Name | Dopamine Beta-HydroxylaseDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase |
| Database Links | Reactome: R-HSA-209905 |
| Cellular Localisation | Soluble Dopamine Beta-Hydroxylase: Cytoplasmic VesicleSecretory Vesicle LumenCytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecretedSecretory Vesicle MembraneSingle-Pass Type Ii Membrane ProteinChromaffin Granule Membrane |
| Alternative Protein Names | Dopamine Beta-Hydroxylase proteinDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase proteinDBH protein |
Information sourced from Uniprot.org