Human DOK4 protein (Recombinant) (His-Tag) (STJP018694)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DOK4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOK4 |
| Gene ID | 55715 |
| Uniprot ID | DOK4_HUMAN |
| Accession Number | NP_060580 |
| Immunogen | Human |
| Immunogen Region | 1-326aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMATNFSD IVKQGYVKMK SRKLGIYRRC WLVFRKSSSK GPQRLEKYPD EKSVCLRGCP KVTEISNVKC VTRLPKETKR QAVAIIFTDD SARTFTCDSE LEAEEWYKTL SVECLGSRLN DISLGEPDLL APGVQCEQTD RFNVFLLPCP NLDVYGECKL QITHENIYLW DIHNPRVKLV SWPLCSLRRY GRDATRFTFE AGRMCDAG |
Additional Info
| Tissue Specificity | Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. |
| Protein Name | Docking Protein 4Downstream Of Tyrosine Kinase 4Insulin Receptor Substrate 5Irs-5Irs5 |
| Database Links | Reactome: R-HSA-8853659 |
| Cellular Localisation | |
| Alternative Protein Names | Docking Protein 4 proteinDownstream Of Tyrosine Kinase 4 proteinInsulin Receptor Substrate 5 proteinIrs-5 proteinIrs5 proteinDOK4 protein |
Information sourced from Uniprot.org