| Short Description : | Recombinant-Human DNAL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE/Denatured |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNAL1 |
| Gene ID: | 83544 |
| Uniprot ID: | DNAL1_HUMAN |
| Accession Number: | NP_113615 |
| Immunogen: | Human |
| Immunogen Region: | 1-190aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAKATTI KEALARWEEK TGQRPSEAKE IKLYAQIPPI EKMDASLSML ANCEKLSLST NCIEKIANLN GLKNLRILSL GRNNIKNLNG LEAVGDTLEE LWISYNFIEK LKGIHIMKKL KILYMSNNLV KDWAEFVKLA ELPCLEDLVF VGNPLEEKHS AENNWIEEAT KRVPKLKKLD GTPVIKGDEE EDN |
| Tissue Specificity | Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis. |
| Function | Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry. |
| Protein Name | Dynein Axonemal Light Chain 1Lc1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium Axoneme |
| Alternative Protein Names | Dynein Axonemal Light Chain 1 proteinLc1 proteinDNAL1 proteinC14orf168 protein |
Information sourced from Uniprot.org
