Human DNAJC2 protein (Recombinant) (N-His) (STJP005891)

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STJP005891
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DNAJC2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DNAJC2
Gene ID: 27000
Uniprot ID: DNJC2_HUMAN
Immunogen Region: Lys442-Lys621
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated in M (mitotic) phase.
Function Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Protein Name Dnaj Homolog Subfamily C Member 2
M-Phase Phosphoprotein 11
Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed
Database Links Reactome: R-HSA-3371453
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Alternative Protein Names Dnaj Homolog Subfamily C Member 2 protein
M-Phase Phosphoprotein 11 protein
Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed protein
DNAJC2 protein
MPHOSPH11 protein
MPP11 protein
ZRF1 protein

Information sourced from Uniprot.org

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