Human DNAJB6 protein (Recombinant) (N-His) (STJP008944)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DNAJB6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DNAJB6 |
| Gene ID | 10049 |
| Uniprot ID | DNJB6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gly124 |
Additional Info
| Function | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity. Isoform B: Isoform B but not isoform A inhibits huntingtin aggregation. |
| Protein Name | Dnaj Homolog Subfamily B Member 6Hhdj1Heat Shock Protein J2Hsj-2MrjMsj-1 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusMyofibrilSarcomereZ Line |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 6 proteinHhdj1 proteinHeat Shock Protein J2 proteinHsj-2 proteinMrj proteinMsj-1 proteinDNAJB6 proteinHSJ2 proteinMRJ proteinMSJ1 protein |
Information sourced from Uniprot.org