Human DNAJB6 protein (Recombinant) (N-His) (STJP008944)

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STJP008944
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DNAJB6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DNAJB6
Gene ID: 10049
Uniprot ID: DNJB6_HUMAN
Immunogen Region: Met1-Gly124
Immunogen: Homo sapiens (Human)
Function Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity. Isoform B: Isoform B but not isoform A inhibits huntingtin aggregation.
Protein Name Dnaj Homolog Subfamily B Member 6
Hhdj1
Heat Shock Protein J2
Hsj-2
Mrj
Msj-1
Database Links Reactome: R-HSA-3371453
Cellular Localisation Cytoplasm
Perinuclear Region
Nucleus
Myofibril
Sarcomere
Z Line
Alternative Protein Names Dnaj Homolog Subfamily B Member 6 protein
Hhdj1 protein
Heat Shock Protein J2 protein
Hsj-2 protein
Mrj protein
Msj-1 protein
DNAJB6 protein
HSJ2 protein
MRJ protein
MSJ1 protein

Information sourced from Uniprot.org

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