Human DNAJB2 protein (Recombinant) (N-GST & C-His) (STJP008826)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DNAJB2-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DNAJB2 |
| Gene ID | 3300 |
| Uniprot ID | DNJB2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala2-Gly91 |
Additional Info
| Post Translational Modifications | Ubiquitinated by STUB1.does not lead to proteasomal degradation. |
| Function | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins. |
| Protein Name | Dnaj Homolog Subfamily B Member 2Heat Shock 40 Kda Protein 3Heat Shock Protein J1Hsj-1 |
| Database Links | |
| Cellular Localisation | Isoform 2: CytoplasmNucleusIsoform 1: Endoplasmic Reticulum MembraneLipid-AnchorCytoplasmic Side |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 2 proteinHeat Shock 40 Kda Protein 3 proteinHeat Shock Protein J1 proteinHsj-1 proteinDNAJB2 proteinHSJ1 proteinHSPF3 protein |
Information sourced from Uniprot.org