Human DNAJB2 protein (Recombinant) (His-Tag) (STJP016928)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DNAJB2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJB2 |
| Gene ID | 3300 |
| Uniprot ID | DNJB2_HUMAN |
| Accession Number | NP_001034639 |
| Immunogen | Human |
| Immunogen Region | 1-277aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMASYYEI LDVPRSASAD DIKKAYRRKA LQWHPDKNPD NKEFAEKKFK EVAEAYEVLS DKHKREIYDR YGREGLTGTG TGPSRAEAGS GGPGFTFTFR SPEEVFREFF GSGDPFAELF DDLGPFSELQ NRGSRHSGPF FTFSSSFPGH SDFSSSSFSF SPGAGAFRSV STSTTFVQGR RITTRRIMEN GQERVEVEED GQLKSVTI |
Additional Info
| Tissue Specificity | More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level). |
| Post Translational Modifications | Ubiquitinated by STUB1.does not lead to proteasomal degradation. |
| Function | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins. |
| Protein Name | Dnaj Homolog Subfamily B Member 2Heat Shock 40 Kda Protein 3Heat Shock Protein J1Hsj-1 |
| Database Links | |
| Cellular Localisation | Isoform 2: CytoplasmNucleusIsoform 1: Endoplasmic Reticulum MembraneLipid-AnchorCytoplasmic Side |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 2 proteinHeat Shock 40 Kda Protein 3 proteinHeat Shock Protein J1 proteinHsj-1 proteinDNAJB2 proteinHSJ1 proteinHSPF3 protein |
Information sourced from Uniprot.org