| Host: |
E.coli |
| Applications: |
SDS-PAGE |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Recombinant-Human Dpolymerase epsilon 3/POLE3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: |
Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% Glycerol, 1mM DTT |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLE3 |
| Gene ID: |
54107 |
| Uniprot ID: |
DPOE3_HUMAN |
| Immunogen Region: |
1-147aa |
| Accession Number: |
NP_059139 |
| Immunogen: |
Human |
| Immunogen Sequence: |
MAERPED LNLPNAVITR IIKEALPDGV NISKEARSAI SRAASVFVLY ATSCANNFAM KGKRKTLNAS DVLSAMEEME FQRFVTPLKE ALEAYRREQK GKKEASEQKK KDKDKKTDSE EQDKSRDEDN DEDEERLEEE EQNEEEEVDN |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. |
| Protein Name | Dna Polymerase Epsilon Subunit 3Arsenic-Transactivated ProteinAstpChromatin Accessibility Complex 17 Kda ProteinChrac-17Huchrac17Dna Polymerase Ii Subunit 3Dna Polymerase Epsilon Subunit P17 |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-5651801Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-68952Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Dna Polymerase Epsilon Subunit 3 proteinArsenic-Transactivated Protein proteinAstp proteinChromatin Accessibility Complex 17 Kda Protein proteinChrac-17 proteinHuchrac17 proteinDna Polymerase Ii Subunit 3 proteinDna Polymerase Epsilon Subunit P17 proteinPOLE3 proteinCHRAC17 protein |
Information sourced from Uniprot.org
