Human DLL4 protein (Recombinant) (No tag) (STJP002904)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human DLL4 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Ser27-Pro524) of human DLL4 (Accession #Q9NR61) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human DLL4-No tag protein was developed in e.coli using the region Ser27-Pro524. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | DLL4 |
| Gene ID | 54567 |
| Uniprot ID | DLL4_HUMAN |
| Immunogen | Recombinant Human DLL4 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Ser27-Pro524) of human DLL4 (Accession #Q9NR61) fused with a His tag at the C-terminus. |
| Immunogen Region | Ser27-Pro524 |
| Immunogen Sequence | RPSGKRPCKMQAFRIWDTNQ KTFYLRNNQLIAGYLQGPNI KLEEKIDMVPIDLHSVFLGI HGGKLCLSCAKSGDDIKLQL EEVNITDLSKNKEEDKRFTF IRSEKGPTTSFESAACPGWF LCTTLEADRPVSLTNTPEEP LIVTKFYFQEDQ |
Additional Info
| Tissue Specificity | Expressed in vascular endothelium. |
| Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Protein Name | Delta-Like Protein 4Drosophila Delta Homolog 4Delta4 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507Reactome: R-HSA-9013700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Delta-Like Protein 4 proteinDrosophila Delta Homolog 4 proteinDelta4 proteinDLL4 proteinUNQ1895 proteinPRO4341 protein |
Information sourced from Uniprot.org