Human DLL3 protein (Recombinant) (N-His) (STJP020109)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CD40L/CD154 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala27-Arg491) of human DLL3 (Accession #Q9NYJ7) fused with His at the N-terminus.
General Information
| Short Description | Recombinant-Human DLL3-N-His protein was developed in hek293 cells using the region Ala27-Arg491. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, 200 mM Arginine, pH 7.4. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | DLL3 |
| Gene ID | 10683 |
| Uniprot ID | DLL3_HUMAN |
| Immunogen | Recombinant Human CD40L/CD154 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala27-Arg491) of human DLL3 (Accession #Q9NYJ7) fused with His at the N-terminus. |
| Immunogen Region | Ala27-Arg491 |
| Immunogen Sequence | AGVFELQIHSFGPGPGPGAP RSPCSARLPCRLFFRVCLKP GLSEEAAESPCALGAALSAR GPVYTEQPGAPAPDLPLPDG LLQVPFRDAWPGTFSFIIET WREELGDQIGGPAWSLLARV AGRRRLAAGGPWARDIQRAG AWELRFSYRARCEPPAVGTA CTRLCRPRSAPSRCGPGLRP CAPLEDECEAPLVCRAGCSP EHGFCEQPGECRCLEGWTGP LCTVPVSTSSCLSPRGPSS |
Additional Info
| Post Translational Modifications | Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. |
| Function | Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. |
| Protein Name | Delta-Like Protein 3Drosophila Delta Homolog 3Delta3 |
| Database Links | Reactome: R-HSA-9793380Reactome: R-HSA-9824272 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Delta-Like Protein 3 proteinDrosophila Delta Homolog 3 proteinDelta3 proteinDLL3 protein |
Information sourced from Uniprot.org