Human DLD (Dihydrolipoyl Dehydrogenase) Sandwich ELISA Kit (STJE0008450)
SPECIFICATIONS
General Information
| Short Description | This DLD Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 1.3U/L |
| Detection Limit | 1.56-100U/L |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | DLD |
| Gene ID | 1738 |
| Uniprot ID | DLDH_HUMAN |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction. |
| Protein Name | Dihydrolipoyl Dehydrogenase - MitochondrialDihydrolipoamide DehydrogenaseGlycine Cleavage System L Protein |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517Reactome: R-HSA-6783984Reactome: R-HSA-70895Reactome: R-HSA-9837999Reactome: R-HSA-9853506Reactome: R-HSA-9858328Reactome: R-HSA-9859138Reactome: R-HSA-9861559Reactome: R-HSA-9865113Reactome: R-HSA-9907570Reactome: R-HSA-9912481Reactome: R-HSA-9912529 |
| Cellular Localisation | Mitochondrion MatrixNucleusCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAcrosomeMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative ELISA Names | Dihydrolipoyl Dehydrogenase - Mitochondrial ELISA kitDihydrolipoamide Dehydrogenase ELISA kitGlycine Cleavage System L Protein ELISA kitDLD ELISA kitGCSL ELISA kitLAD ELISA kitPHE3 ELISA kit |
| output |
Information sourced from Uniprot.org