Human DKKL1 protein (Recombinant-Active) (C-10*His) (STJP012315)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human DKKL1-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit proliferation of human cervical epithelial carcinoma cells (HeLa). The ED50 for this effect is 2-6 µg/mL. |
Target Information
| Gene Symbol | DKKL1 |
| Gene ID | 27120 |
| Uniprot ID | DKKL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala31-Leu242 |
Additional Info
| Post Translational Modifications | N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm. |
| Function | Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. |
| Protein Name | Dickkopf-Like Protein 1Cancer/Testis Antigen 34Ct34Protein Soggy-1Sgy-1 |
| Database Links | |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory VesicleAcrosomeLocalized Specifically To The Crescent Shaped Acrosome At The Apex Of The Sperm Head |
| Alternative Protein Names | Dickkopf-Like Protein 1 proteinCancer/Testis Antigen 34 proteinCt34 proteinProtein Soggy-1 proteinSgy-1 proteinDKKL1 proteinSGY1 proteinUNQ735 proteinPRO1429 protein |
Information sourced from Uniprot.org