Human DKK4 (DKK4) Antibody Pair (STJAP00929)
General Information
| Short Description | This DKK4 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1mg/mL |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DKK4 |
| Gene ID | 27121 |
| Uniprot ID | DKK4_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Expressed in cerebellum, T-cells, esophagus and lung. |
| Post Translational Modifications | Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 4Dickkopf-4Dkk-4Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Dickkopf-Related Protein 4 antibody pairDickkopf-4 antibody pairDkk-4 antibody pairHdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form antibody pairDKK4 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human DKK4 (DKK4) Antibody Pair (STJAP00929)
This antibody pair is designed to detect human DKK4 (UniProt Q9UBT3) and has confirmed reactivity against the human form of the protein. It is intended for research use only and is not validated for non-human species based on the provided product information.
This antibody pair has been validated for use in ELISA. No other assay formats are listed in the product specifications.
Both antibodies are supplied as unconjugated rabbit monoclonal IgGs at 1 mg/mL, formulated in 0.01M PBS at pH 7.2, and purified by affinity chromatography. Neither antibody carries a conjugate or tag, so detection antibody labeling will need to be performed or arranged by the end user.
Optimal working dilutions for both antibodies are determined by the end user and are not defined in the product specifications. Titration experiments are recommended to establish the appropriate concentrations for the intended assay setup.
Both antibodies were raised against a recombinant protein immunogen corresponding to human DKK4. No further detail on the immunogen region is provided in the product specifications.
Both components should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C, avoiding repeated freeze/thaw cycles to preserve antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.